An engineered 5-helix bundle derived from SARS-CoV-2 S2 pre-binds sarbecoviral spike at both serological- and endosomal-pH to inhibit virus entrySARS-CoV-2 S2에서 파생된 조작된 5나선 번들은 바이러스 진입을 억제하기 위해 혈청학적 pH와 엔도솜 pH 모두에서 사베코바이러스 스파이크를 사전 결합합니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, [키워드] 5-helix bundle (5HB) acute respiratory syndrome acute respiratory syndrome coronavirus bind binding Broad-spectrum inhibition can not cell membrane construction coronavirus Evidence feature fusion heptad repeat highlighting host cell host cells IC50 infections inhibit neutralize peptide peptides pre-fusion predominant Protein sarbecovirus sarbecovirus Sarbecoviruses SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 S2 SARS-CoV-2 variant SARS-CoV-2 variants serological severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 structural basis These data Treatment viral entry viral entry. viral spike virus entry virus infection [DOI] 10.1080/22221751.2022.2095308 PMC 바로가기 [Article Type] Article
Breadth of SARS-CoV-2 neutralization and protection induced by a nanoparticle vaccineArticle Published on 2022-10-232022-11-15 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] adjuvant anticipated Beta COVID-19 Delta delta variant domain effective ferritin Heterologous highest Immunity induce Infection mice mutations neutralization neutralization titer neutralizing antibody NHP NHPs non-human primate omicron PROTECT pseudovirus reported sarbecovirus Sarbecoviruses SARS-CoV SARS-CoV-2 SARS-CoV-2 neutralization SARS-CoV-2 variant SARS-CoV-2 variants SARS-related viruses Vaccine variant [DOI] 10.1038/s41467-022-33985-4 PMC 바로가기
Priming conditions shape breadth of neutralizing antibody responses to sarbecovirusesArticle Published on 2022-10-212022-11-15 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] BNT162b2 BNT162b2 vaccine breadth Breakthrough infection Cohort Combination condition cross-neutralization cross-protective dose elicit highest immunized inactivated include individual Infection magnitude mRNA multiplex neutralization Neutralization assay neutralizing antibody Neutralizing antibody response of BNT162b2 omicron public health Receptor binding domain sarbecovirus sarbecovirus Sarbecoviruses SARS-CoV-1 SARS-CoV-1 infection SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant sera Sinopharm vaccination Vaccine Vaccine design Virus spike viruses [DOI] 10.1038/s41467-022-34038-6 PMC 바로가기
Evolutionary remodelling of N-terminal domain loops fine-tunes SARS-CoV-2 spikeArticle Published on 2022-10-062022-11-16 Journal: EMBO Reports [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] analyses Analysis antigenic variation complex COVID-19 Critical Deletion exacerbated fine-tune flexible functional Health Host Immunity mechanism membrane fusion Modification modulate Mutation N-terminal domain NTD omicron polymorphism receptor engagement remained responsible reveal Sarbecoviruses SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant spike spike glycoprotein spike stability variant variants variants. Variation Viral transmission virus entry [DOI] 10.15252/embr.202154322 PMC 바로가기
Vaccine-elicited murine antibody WS6 neutralizes diverse beta-coronaviruses by recognizing a helical stem supersite of vulnerabilityArticle Published on 2022-09-012022-11-15 Journal: Structure (London, England : 1993) [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome analysis antibodies antibody beta-coronavirus beta-coronavirus beta-coronaviruses Broadly neutralizing antibody conformations conserved coronavirus COVID-19 crystal structure elicit hydrophobic residue immunized indicated inhibiting Middle East mRNA murine neutralization neutralize neutralized Neutralizing recognizing S2 subunit S2-directed antibody Sarbecoviruses SARS-CoV SARS-CoV-2 SARS-CoV-2 variants spike syndrome the antibody the SARS-CoV-2 Vaccine design Vaccine design. [DOI] 10.1016/j.str.2022.06.004 PMC 바로가기
A Multitrait Locus Regulates Sarbecovirus PathogenesisArticle Published on 2022-08-302022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 진단, [키워드] acute respiratory syndrome analysis approach CCR9 chromosome 9 collaborative cross conserved coronavirus coronavirus disease Coronavirus infection cross CXCR6 disease facilitate Follow-up Genes Genetic genetic determinant genetic mapping Genetic variation GWAS help highly pathogenic Host host response host susceptibility humans identify implementation Infection Infectious disease influence loci locus mice Mortality mouse model outcome outcomes Pathogenesis pathogenic Precision predict Protective regulate sarbecovirus Sarbecoviruses sarbecoviruses. SARS-CoV SARS-CoV infection SARS-CoV-2 SARS-CoV-2 infections severe disease severity strain susceptibility susceptibility allele variety Viral diseases Virus Disease [DOI] 10.1128/mbio.01454-22 PMC 바로가기
High activity of an affinity-matured ACE2 decoy against Omicron SARS-CoV-2 and pre-emergent coronavirusesOmicron SARS-CoV-2 및 사전 출현 코로나바이러스에 대한 친화성 성숙 ACE2 유인물의 높은 활성Article Published on 2022-08-252022-09-11 Journal: PLoS ONE [Category] SARS, 변종, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adeno-associated virus affinity airway angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antigenic antigenic drift binding can not clade complicate coronavirus coronavirus coronavirus disease Coronavirus disease 2019 Coronaviruses COVID-19 COVID-19 pandemic decoy develop drug Efficacy Evolution exceptional genetic diversity human ACE2 inhibitor intranasal intrinsic mitigate monoclonal antibody mutant nanomolar affinity Neutralizing omicron pandemic populations preparation Prophylaxis receptor Receptor-binding domain sarbecovirus sarbecovirus Sarbecoviruses SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus Spike protein the SARS-CoV-2 the spike protein therapeutic Threats Treatment Vaccine variant variants viral evolution viral genome viral spike viral strain viral strains virus virus widespread zoonotic [DOI] 10.1371/journal.pone.0271359 PMC 바로가기 [Article Type] Article
Variation in synonymous nucleotide composition among genomes of sarbecoviruses and consequences for the origin of COVID-19사베코바이러스 게놈 간 동의 염기 조성의 변이와 코로나19의 기원에 대한 영향Article Published on 2022-08-152022-09-11 Journal: Gene [Category] COVID19(2023년), SARS, 치료기술, [키워드] analysed bat bat virus Bulgaria China Codons consequence coronavirus COVID-19 COVID-19 pandemic cytosine degenerate diagnosed dinucleotides distribution eight Evidence evidence of explain feature FIVE Genome genomes group horseshoe bat Host host cell host cells include independent intermediate intermediate host Japan Kenya less Manis javanica mutations nucleotide pangolin pangolins RdRP RdRp selection Recombination reservoir Reservoir host responsible sarbecovirus sarbecovirus Sarbecoviruses SARS epidemic SARS-CoV SARS-CoV-2 subgenus synonymous Synonymous mutations. the SARS epidemic uracil viral replication viruses [DOI] 10.1016/j.gene.2022.146641 PMC 바로가기 [Article Type] Article
Mosaic RBD nanoparticles protect against challenge by diverse sarbecoviruses in animal modelsArticle Published on 2022-08-052022-10-06 Journal: Science (New York, N.y.) [Category] SARS, 조류인플루엔자, 진단, [키워드] acute respiratory syndrome animal model antibody betacoronavirus conserved coronavirus demonstrated elicit elicited epitope Health immune response immunization immunodominant macaque mice mosaic neutralization PROTECT Randomly RBD RBDs response sarbecovirus sarbecovirus Sarbecoviruses SARS-CoV SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Seven spike receptor-binding domain Strains variant [DOI] 10.1126/science.abq0839 PMC 바로가기 [Article Type] Article
Humoral responses to the SARS-CoV-2 spike and receptor binding domain in context of pre-existing immunity confer broad sarbecovirus neutralization기존 면역의 맥락에서 SARS-CoV-2 스파이크 및 수용체 결합 도메인에 대한 체액 반응은 광범위한 사베코바이러스 중화를 부여합니다Article Published on 2022-08-042022-09-12 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] approved B cell response Candidates clinically coronavirus elicited Epitopes evaluated Evaluating Humoral response IgG immune immune imprinting immune response immunization Infection naïve neutralization pre-existing immunity RBD reactivity Receptor binding domain receptor binding domain (RBD) regimen sarbecovirus Sarbecoviruses SARS-CoV-2 serum spike (S). spike glycoprotein the SARS-CoV-2 vaccination vaccine candidate [DOI] 10.3389/fimmu.2022.902260 PMC 바로가기 [Article Type] Article